In recent diabetic news, Kombiglyze XR, a popular medication to treat type 2 diabetes, has recently been linked with heart failure, as well as other serious Kombiglyze XR side effects.

Kombiglyze XR (saxagliptin and metformin hydrochloride) and other diabetes drugs in the incretin mimetics class are used to help control type-2 diabetes.

They do this by regulating high blood sugar levels. These diabetes drugs are supposed to be taken along with diet and exercise.

The saxagliptin in Kombiglyze XR is used to stimulate insulin production in order to regulate a patient’s blood sugar levels. The metformin decreases glucose (sugar) production in the liver and decreasing glucose absorption in the intestinal tract.

Kombiglyze XR is manufactured by Bristol-Myers Squibb, and is marketed by BMS and AstraZeneca Pharmaceuticals.

Though incretin mimetics are a relatively new group of diabetes drugs, there have already been reports of serious Kombiglyze XR side effects, including heart failure. Experts are currently trying to determine the potential risks that may be associated with these diabetes drugs.

Kombiglyze XR and Heart Failure

A study funded by saxagliptin manufacturers, known to the medical community as the SAVOR study, evaluated 16,492 type-2 diabetes patients. The study found that patients who took saxagliptin were hospitalized due to heart failure at a slightly higher rate than those who did not use saxagliptin, and used other type-2 diabetes drugs instead.

Heart failure is a serious and potentially life-threatening medical condition in which the heart becomes so weak that it cannot adequately pump blood throughout the body. High blood pressure or coronary artery disease can eventually lead to heart failure by gradually weakening the heart.

Even if a patient survives heart failure, they are typically forced to make significant changes to their daily life. These kinds of permanent changes may include improving their diet, reducing their level of salt intake, exercising, losing weight, and/or managing stress more effectively. All of these things can reduce the risk of further complications.

The SAVOR study did find that patients who took saxagliptin were hospitalized at a higher rate, but this increase was not considered to be statistically significant. Nevertheless, some experts believe that this potential link between saxagliptin and heart failure deserves further investigation.

Kombiglyze XR Side Effects

Kombiglyze XR, and other similar drugs, have been linked with the following serious side effects:

• Heart failure
• Thyroid Cancer
• Pancreatitis
• Acute Pancreatitis
• Hemorrhagic Pancreatitis
• Necrotizing Pancreatitis
• Kidney Complications
• Renal Failure

Kombiglyze XR Lawsuits

Diabetes drugs like Kombiglyze XR and Onglyza have faced an increasing number of heart failure lawsuits in recent months.

Many people allege that ingesting saxagliptin directly led to major Kombiglyze XR side effects, including heart failure, reporting that the drug’s manufactures failed to adequately warn and inform the medical community and consumers of potential heightened risk factors of their drug.

Studies have found other potentially serious and even life-threatening Kombiglyze XR side effects besides heart failure. Kombiglyze has also been connected to increased pancreatic and thyroid cancer risks, and people have begun filing Kombiglyze pancreatic cancer and Kombiglyze thyroid cancer lawsuits.

Many injured parties are choosing to file Kombiglyze heart failure lawsuits. If you or someone you know has suffered from heart failure after using Kombiglyze or from Onglyza, you may be able to file a Kombiglyze heart failure lawsuit.